In that book, a wet bulb event (high humidity and high temp) in India pushes infrastructure past the breaking point, the grid goes down, AC systems still running on generators are overloaded and overcrowded and fail, the water temp goes over body temp, and millions die.
The positive cultural/societal reaction to the disaster strained my suspension of disbelief pretty hard, as is typical of KSR novels in my experience, but the idea of a heat wave causing a massive catastrophe (and the poignant description of attempting to live through it) stuck with me.