Most musicians aren't aware of this, but an interesting corollary of the circle of fifths is the Pythagorean Comma: http://en.wikipedia.org/wiki/Pythagorean_comma#Circle_of_fif...
We generally treat Gb and F# as the same note, but if you actually count perfect Pythagorean fifths (frequency ratios of 3:2) in both directions from C, Gb and F# don't actually perfectly meet in the middle!