When you have two monitors, is your head always turned to one side? That always hurts my neck, so I wind up with the second monitor relegated to the side, where I never actually look at it.
The ultra wide above was mainly dedicated to various chat programs (teams, telegram, iMessage, etc).
The laptop's screen to the left was my mail screen (both home and work).
To the right was a 4k on its side, for documentation reference or output work.
And above the laptop was a "scratch" monitor for whatever was needed (often a music player, etc).
You quickly get used to glancing at what you need and moving on; if something needs more attention it's easy to bring it front and center or turn your chair.
Power fluctuations took out the ultrawides and one of the 4ks so now I just have one supermegaultrawide with a 4k above it (still laptop for mail, "above" for chat, and main for main things).
Wouldn’t recommend it, but I already had it.