Actually, the old Kindle had physical buttons, which I find more ergonomic when reading in bed
But then I also understand that'd increase the price by 10% and only help right handed people with weak hands so... c'est la vie.
You can... turn them upside down to become a left-handed device. That way you can be weak-handed with either hand!
If you turn it upside down the left hand buttons will be way too high on the reader
I was skeptical of the "lopsided" design at first but it grew on me and is what I'd prefer in future devices from here on out.