It's important to quickly get desensitized to this, because if you're even moderately successful, the volume of YouTube quality feedback directed at your very own pride and joy can quickly become overwhelming.
The really mean stuff never bothered me, nor the comments that seemed like they were Markov chain generated.
My biggest weakness was always idiocy - and trust me, I picked the wrong profession for that. Comments in the form of:
Great game! (rating set to 1/5)
Clone of [shitty clone of my game]
How do you shoot??? (rating set to 1/5) (game has no weapons)
[complaint about another game on the front page that day] (rating 1/5)
Got [incredibly low score]!!! (game has global high score functionality)
I bought this where do I download (game not for sale)
Unfortunately from memory, since I don't save any of it. But you get the idea.