Learning about B2B sales over the years, the size of this leadership-change factor has been among the most eye-opening (and among the most disappointing).
It cuts both ways: You can have a successful pilot that doesn't proceed because this-or-that VP was replaced, and to show off their bold new direction, the new VP cancels almost everything novel the previous person started. Or you can reach out just at the moment the new guy or gal comes in, right when they're looking for the pieces of their bold new direction, and you become part of that.
I would love to have later learned that leaders who evaluate opportunities separate from personal attachment are seen as more efficient, better, and selected favorably; that more successful companies are less subject to this sort of political/careerist whimsy. Alas. At least I have been fortunate enough to experience both directions in quantities that roughly balance out.