An experienced guitarist cannot distinguish between "captured" amps, or amps which at their core simulate vacuum tubes at the software level. I definitely can't tell the two apart. However, I believe it is easy to distinguish a pure vacuum tube-based circuit from a JFET/MOSFET-based one.
There do exist vacuum tube replacements like the AMT 12AX7WS [1] or Jet City's RetroVales [2], but I would argue that the fact that they try to emulate tubes via transistors is a strong indicator that the natural circuits for both sound distinct enough for guitarists.
[1] https://amtelectronics.com/new/amt-12ax7ws/
[2] https://web.archive.org/web/20190803060713/http://www.robert...
The two products you list are proof of that.
Also, some 90's lower end amps with a valve in the prev sounded way better than similar priced amps that opted for pure solid state, at least for metal music and high distortion. For the clean channel the difference between them was minor.
One very common trick that has appeared in transistor guitar amps from the 1970's and onward is current feedback. The return terminal of the speaker doesn't go straight to ground, but feeds a tiny current-sensing resistor, like 0.1 ohms. Signal from the current-sensing resistor is combined into the negative feedback. This gives the amp a nonzero output impedance against the speaker, which changes the frequency response: more power is driven at the frequencies where the speaker impedes more, like its resonant frequency (about 70 to 100 Hz for a 12" guitar speaker) and high frequencies (due to voice coil inductance: rises from about 2 kHz up or something like that).
This doesn't reproduce everything that happens with tubes, but it goes a long way.
I built a circuit like that into an off-the-shelf amplifier, with a switch. I tell you, whenever I switch that off, it's not long before it goes back on again. Without the current feedback, it's sounds blatty/tubby and lifeless. It's not just the frequency response, because even if we dial in a similar EQ curve before the amp to eliminate the difference, it's not "it".
The TubeWorks people have an interesting design in the MosValve 500 amp. Rather than using current feedback, that amp places the MOSFET output stage outside of the negative feedback loop. Negative feedback is drawn from the VAS (voltage amplification stage) before the output stage. That means that the speakers will see the impedance of the MOSFETs. Plus the supposedly "tube like" overdrive characteristics of the power devices will come into play when that thing is cranked. Because they are outside of the NFB loop, it will just be soft onset clipping. Here is the important thing: unusually, the VAS and the output stage are on separate power rails, and those of the VAS are a significantly higher voltage (+/- 93V versus +/- 71V). So it is hard to make the VAS clip; it requires a much higher signal than what it takes to make the output stage go into progressive clipping. When an output stage is included the feedback loop, like in almost every amplifier out there, the amp is perfectly linear up to the limit, and then clips really hard.
The schematic: https://img.photobucket.com/albums/v202/xr3drumx13/MV500Sche...
Tube amplifiers "do their thing" without extra gimmicks like this, though.