MitM is not possible if one uses public key authentication.
Specifically, if you bind authentication to the connection, then an attacker who impersonates the server (in this case because it's the first connection, but in other settings because they have a fake certificate), then client authentication is not portable to another connection, so the attacker can't mount a classic MITM attack. However -- and this is a big however -- that doesn't mean that there aren't serious security problems. For example:
* If you use SSH to copy a secret such as an API key to the server, then the attacker still knows the API key.
* If you download some file (e.g., a script) from the server and then trust it, the attacker can use that to provide a malicious script.
That's much harder to pull off though, because you need to replicate the environment close enough so that the victim doesn't suspect anything. Do they put their config files in /var/lib or random docker volumes? Do they use docker compose or docker-compose, etc.