Overall I think there is going to be a lot of "old" gpu compute hanging around, and now that writing kernels is a lot easier than it has been, we might as well try and see what algorithms we can get working there.
I originally picked up Mojo for the SIMD, not for the GPU kernels. The SIMD usability in Mojo is outstanding.
Paper on the tool I wrote: https://doi.org/10.1093/bioadv/vbaf292
What's "alignment" in your context. In bioimaging it usually refers to aligning something to a reference atlas (like the Allen Reference Mouse Brain Atlas) or aligning two microscope channels (like the red channel and green channel)
I have been pretty hopeful about Mojo as I find many of the modern compiled languages these days requires an surprisingly excessive amount of ceremony just to open a file and read it line by line. At least this is the case with Go, as I've written about [1].
If Mojo is providing any kind of python like experience in this matter, I will be all into it again (it lacked these features when I last tried).
The syntax i Mojo really seems to shine a lot ... though I still wonder if the train has already left now that so much bioinfo work is already done in Rust.