For normal plates this should not be a problem. Normal Colorado license plates have the format XXX-XNN where Xs are letters and Ns are digits. Someone getting 0 and O mixed up when entering a plate into a database should not cause false matches. It should only cause false mismatches.

I'd guess then that it must be vanity plates in these incidents. The state should fix that by not allowing a vanity plate to be issued that only differs from another vanity plate by 0/O changes. (Maybe also filter out 1/I changes).

That's what I was thinking. You can see in one photo on the article that the O is squared off, and the zero is rounded, but it still seems ripe for confusion.