Yes.
I currently am working on a web-app using cherrypy for my client, who has some small knowledge of PHP.
He's a great guy, and I love working with him; however, he likes to make suggestions, normally involving some way he could implement something in PHP to help out, and the suggestions invariably would add a lot of unnecessary complexity when a simpler solution is already available.
Not that his ideas are bad; they're almost always good ideas on a high level, but just really bad fits as far as implementation details go - normally of the "Yes, we can just kinda glue all this different stuff together" type, which is fine sometimes, but since we're using python there tends to be readily available solutions that don't involve all the overhead of gluing stuff together.