Well, I've done a LOT more than that, and it's still generally $20s, except for certain ATMs in certain casinos. Even in casinos that have ATMs that hold $100s, only a few certain ones generally do. The Wynn is the only casino I know of where all of them have $100s.
And most non-casino ATMs have a per transaction limit of $600-$800, independent of your card's limit. You can do multiple transactions, but you'll get $20s every time. This too varies a bit in Vegas and AC, where you can find much higher limits, but again only in the right ATMs in the right casinos.
Vegas casinos have a rule that they will only trade you up to $500 in $100s for lower denominations per casino per day. It's to prevent laundering. The Feds absolutely hate $100 bills because of that. If the FBI were able to get rid of them, they would in a heart beat.
Since I made most of my money playing online poker and withdrew it that way, I would often spend hours each day walking up and down the strip cashing $20s in for $100s.
I've never understood why $50s weren't used more. It seems like the optimal bill. Spitting out $500 in them isn't objectionable, and I imagine a lot of people withdraw $50 (or would if you made it a quick cash option).