"Note that alcohol (despite being legal and used more often than the other drugs) is by far the most harmful; not only is it the most damaging to societies, it is also the fourth most dangerous for the user. Most of the drugs were rated significantly less harmful than alcohol, with most of the harm befalling the user."

Thanks! Yes, a legal drug that is more widespread and more studied has more aggregate impact. Another sentence in that link specifically calls out legal and cultural impacts on harms. This is also in the UK, so it's worth noting there could be differences with the US. This does not negate my statement and in some areas bolsters it (data discrepancy claims).

I thought pretty much any barbituate, benzo, and some opioid based drugs would can also do that.