Say you have a GPU with 20GB of VRAM. You're probably going to be able to run all the 3-bit quantizations with no problem, but which one do you choose? Unsloth offers[1] four of them: UD-IQ3_XXS, Q3_K_S, Q3_K_M, UD-Q3_K_XL. Will they differ significantly? What are each of them good at? The 4-bit quantizations will be a "tight squeeze" on your 20GB GPU. Again, Unsloth steps up to the plate with seven(!!) choices: IQ4_XS, Q4_K_S, IQ4_NL, Q4_0, Q4_1, Q4_K_M, UD-Q4_K_XL. Holy shit where do I even begin? You can try each of them to see what fits on your GPU, but that's a lot of downloading, and then...
Once you [guess and] commit to one of the quantizations and do a gigantic download, you're not done fiddling. You need to decide at the very least how big a context window you need, and this is going to be trial and error. Choose a value, try to load the model, if it fails, you chose too large. Rinse and repeat.
Then finally, you're still not done. Don't forget the parameters: temperature, top_p, top_k, and so on. It's bewildering!