And for sites that don't have insufficiently permissive email regex validators, if you have gmail you can just add a '+' and do youremail+skype@gmail.com, youremail+facebook@gmail.com, etc.
So if your goal is to maintain email-provider independence, then relying on provider-specific features like the '+' modifier works against that goal.
For me though, the main reason I don't use it is most sites that I want to use it on reject the '+' in the address as invalid. It happens enough that I don't bother trying anymore.