it's used extensively

Babashka, which is Clojure for scripting, is the Small Clojure Interpreter compiled to a native executable

That said, it does limit you a little b/c with Graal native you need to tell the compiler if you will dynamically use a type/class (so it can't be inferred during compilation). The compiler is doing what JS people call "tree shaking" to strip unused code. (dead code elimination in C++ terms) As I understand it you have some annotation file so you don't eliminate too much, similar to using Proguard. So it's mostly plug-n-play but with some caveats