Not to mention the muscle memory for pressing CTRL in the corner of the keyboard rather than CMD where Alt is.
Though I will say that having "Copy" (cmd-c) being different from ^C (ctrl-c) was kind of nice. Though Terminal has done a nice thing of making it so if you highlight text, Ctrl-C copies the first time you press it, and sends ^C the second time.
Which is to say that neither Windows nor Mac shortcuts are inherently better. It's just what we're used to. IME, the main difference is that once you learn the Mac shortcuts in a handful of apps, they'll pretty much work on the other apps you encounter, too.
The real WTF is who thought putting "close window/tab" and "exit browser" on adjacent keys was ever a good idea.
It's not like you can't change it.
System Settings > Keyboard Shortcuts > App Shortcuts > add your browser > remap the Reload menu item to F5
Along with Karabiner you can pretty much make Mac OS work however you want it to when it comes to keyboard shortcuts.