We invited the strippers, JFK, and Stalin to the party. [three groups invited - strippers, a president, and a premier]
We invited the strippers, JFK and Stalin to the party. [the president and premier are strippers]
Very different visual conjured by those two sentences.
"John helped his uncle Jack off a horse"
Two very different outcomes...
John helped his uncle, Jack, off a horse.
Because while speaking it I only pause after uncle and "Jack off a horse" together next. feels like there should be another pause after Jack?
We invited the strippers, JFK and Stalin, to the party [two strippers, named JFK and Stalin]
if the goal is to minimize ambiguity.
There is no suggestion that one would do this in "regular" text.
That said:
We invited the stripper, JFK, and Stalin to the party.
We invited the stripper, JFK and Stalin to the party.
The supposed ambiguity is back. Although again there is no ambiguity to the reader. The juxtaposition of the two versions wouldn't work as a joke if there was any ambiguity
We invited the strippers, Krystal and Britney, to the party.
We invited the strippers, Krystal, and Britney, to the party.
And yes, if strippers is made singular, poor Krystal becomes Schrödinger‘s Stripper.