I'm so married to my existing tmux workflows and layout that I'm not sure whether I'd ever feel open to trying out something like this. At the same time, orchestrating multiple agents with native tmux and git worktree does feel cumbersome.
Having a pane dedicated to some LLM prompt split side by side with your code editor doesn't require additional tools, it's just a tmux hotkey to split a pane.
There's also plugins like tmux resurrect that lets you save and restore everything, including across reboots. I've been using this set up for like 6-7 years, here's a video from ~5 years ago but it still applies today https://www.youtube.com/watch?v=sMbuGf2g7gc&t=315s. I like this approach because you can use tmux normally, there's no layout config file you need to define.
It lets me switch between projects in 2 seconds and everything I need is immediately available.