Being open to new experiences, in my opinion, is much more a matter of the people you surround yourself with, than with physiology. Sure, your brain may change a little bit in your 20s and not so much in your 30s, but if you have the right friends, perhaps some younger friends, they will drag you into new things.
I have felt that palpably running my own company for the last 5 years. In the first few years, it was just my wife and I doing everything, writing the code and running the business. As we started to make enough money that we could hire people, I started to notice how set in our ways we became.
Since we had started writing iPhone apps near the beginning of the mobile revolution, our code was written to suit older devices. In places, we did things for performance reasons so our apps would work well on old phones. Also, we never adopted ARC, because that's just not how we did it. But as we started to hire people, our engineers pushed us to change our old ways, and as a result, our code became much better.
So, I say - don't fear the reaper. Just find some young friends (or employees). I turned 30 this year, so I have a few gray hairs, but working with people in their 20s really has changed my ideas on the right way to do things, and given me perspective on my own life.