FWIW I tried it with the VSCode preview in two monorepos we have - one frontend and one backend GraphQL servers with complex types - absolutely no issues (except one breaking change in tsconfig with baseUrl being removed) and fast compile times.
The moduleResolution: node deprecation is the one I'd flag for anyone not paying attention yet. Switching to nodenext forced us to add .js extensions to all
relative imports, which was a bigger migration than expected.
Compilation speed improvement is real though. Noticeably faster on incremental builds.