Anecdotal, but I asked Claude the other day about how to dilute my medication (HCG) and it flat out refused and started lecturing me about abusing drugs.

I copy and pasted into ChatGPT, it told me straight away, and then for a laugh said it was actually a magical weight loss drug that I'd bought off the dark web... And it started giving me advice about unregulated weight loss drugs and how to dose them.