Yes, the Mac Neo will tell you you’re plugging in to the wrong port!
And while the ports aren’t labeled, if you plug an external display into the “wrong” port, you’ll get an on-screen notification suggesting you plug it into the other port. [1]
And while the ports aren’t labeled, if you plug an external display into the “wrong” port, you’ll get an on-screen notification suggesting you plug it into the other port. [1]
The notification is hardware based; the manufacturer of a USB keyboard or mouse won’t matter.
If you plug a hard drive into the slow USB port, macOS will let you know.
There have been thousands of different USB devices plugged into Macs since they adopted it in 1998; I doubt there’s going to be problems now.