Their challenge is, how do we halve the price and yet deliver twice the quality? I think they are going to realize they can't. Some of them will leave the market.
A nitpick: there are two USB ports, one of them is a 10GB/s USB 3 port.
"you're plugging it wrong" will become the new version of the classic "You're holding it wrong"
And while the ports aren’t labeled, if you plug an external display into the “wrong” port, you’ll get an on-screen notification suggesting you plug it into the other port. [1]
The notification is hardware based; the manufacturer of a USB keyboard or mouse won’t matter.
If you plug a hard drive into the slow USB port, macOS will let you know.
There have been thousands of different USB devices plugged into Macs since they adopted it in 1998; I doubt there’s going to be problems now.