Guitars certainly have a more intimate connection between the touch of fingers and the sound, including the bending of the tone, one of Hendrix’s virtuosities.

Keyboards can approach that with polyphonic touch keys like the Hydrasynth (lean into keys, pressing them harder, for bending the tone in a configured patch), sustain pedals, and pitch bend/modulation controls, but not the nuanced touch of skin on a vibrating string.

I think synth guitars exist, too, but don’t know anything about them. The pedalboards are enough, maybe :)