If there is no inside to a box, then knowing everything about how the box interacts with things outside the box, is pretty much everything there is to know about the box, yeah.
The study of physics concerns only that which we can observe/measure. Now, like I implied before, I’m not a scientific materialist, and I don’t claim that all-that-there-is is amenable to understanding through the lens of physics. So, like, I guess the answer is “No, I don’t expect physics to tell us everything I want to know about the nature of the universe, just all of it that is accessible to experiment.”.