I read a book that said you should try something new to you at least every quarter if not more often. It gives you something to talk about.
While my wife and I are empty nesters and at point where we travel a lot and we do the digital nomad thing in spurts so we can always talk about travel or more often ask “what’s the most interesting place you’ve been to”/“What’s interesting about where you live” etc, it doesn’t have to be travel.
And just to be clear, it’s always either guys I am striking a conversation with or couples. There is no way for a 50 year old married guy to talk to a woman alone at the bar without coming off like a creep.
On the other hand, I try not to talk about politics or religion. What’s the point?