One of the geneticists who worked on identifying this is also on HN and tried to explain this [2] but HNers think they are smarter than actual leaders in the fields of genomics.
[0] - https://www.mpg.de/10973923/why-do-scientists-investigate-mi...
[1] - https://www.mpg.de/8949327/structural-variants-crispr-cas
Or in other words the meat of the critique is not aimed at genomics, but rather in science marketing.
The reality is every theraputic has some kind of negative side effect, which may reduce the incentive for it to be productionized becuase the whole point about medicine is harm reduction.
Passing the hurdle of being viable in mice is a major hurdle because in most cases, experiments fail. And if it's efficacy is proven in mice, it shows viability in a specific approach and justifies investing the hundreds of millions of dollars in trying to bring something to Phase 3.
Because it happens in a regime that intentionally makes it so.
That's not how e.g. vaccination got invented now is it.
Busy-bodies too busy "protecting us from ourselves" to let us find cures.
Anatomically and behaviorally, primates would still be the top choices there. And many, many disciplines experiment on animals, where results don't come at the genetic level.
Good, the genetics match closely. But mice (or rats: see the idiom "lab rat") are also considered vermin, prolific breeders, fit in your hand, short life-cycle, and easily obtained. So they join fruit flies in the lab experiments.
Interestingly, pigs are used in many types of medicine while not enjoying that genetic similarity. In the 1950s and 60s, your insulin and thyroid meds were often derived from pigs.
Because you typed a number that looks close to 100%. So must be basically the same.
It’s a relative of Betteridge’s Law of Headlines.