A psychedelic medicine performs well against depression

Pharma, sprang up from taking wondrous compounds found in nature and isolated them or refined them into new compounds that they could patent, market, and sell to consumers.

Ibuprofen, for example, is crude oil.

Conspirator's advocate says that bigPharma has synthesized and patented every active plant compound so that keeping the actual plants scheduled is to their benefit.

A company can develop a formulation of generic, off-patent compounds and get FDA approval for that patented formulation.

Even old off-patent drugs are often brought back in new, on-patent formulations that can't be sold generically until the expiration of the patents on the formulation that was approved.

So even if they used psilocybin, they would get a patent on their formulation and get FDA approval for that formulation.

It's never going to be a major moneymaker - you rarely encounter people who want to continue abusing it. 1 dose is sufficient for 6 or more months of mitigated symptoms, sometimes even allowing people to entirely escape negative thought patterns and depression. Psilocybin induces new synaptic pathways, helps balance out or suppress obsessive loops, so in combination with positive reinforcement in lifestyle patterns, habits, and changing environments, a single high dose psilocybin experience can radically alter someone's mental health and outlook for the better.

The literature is fascinating - one of the safest drugs known to science, yet one of the least exploited for medical or scientific purposes. There's a whole vast wealth of good data that will come from research like this, it's exciting.

> I used to think that the alternative medicine people were overestimating how evil Big Pharma was. But now I know that’s not right.

> Now I know they’re underestimating it.

> If it were discovered tomorrow that potatoes cured cancer, then people wouldn’t “suppress” this “natural” remedy. Two years from now there would be an ultrapurified potato extract called POTAXOR™®© that was, on closer examination, physically and chemically identical to mashed potatoes. But these mashed potatoes would be mashed in a giant centrifuge by scientists with five Ph. Ds each. Any time someone got cancer, their doctor would prescribe POTAXOR™®© and charge $6,000 per dose, and the patient would get better, and the thought of just going out and eating a potato would never occur to anybody. Not to the doctor, who doesn’t want to sound like the idiot who tells her cancer patients to eat potatoes. Not to the FDA, who doesn’t know whether potatoes might be contaminated with lead or potato fungus or ketchup or God-knows-what. And certainly not to the patient. They would have to pay 60 cents for a potato at the supermarket, but if they have a good enough insurance the POTAXOR™®© is free!

> This system, bizarre as it is, is your guarantee against the pharmaceutical companies suppressing a promising new natural medication. Your insurance company pays $300 on fish oil, and in exchange you go to sleep at night secure that no one has discovered that potatoes cure cancer but decided to cover it up to protect their bottom line. Good deal? Given the current health system, it’s better than you had any right to expect.

Potatoes aren't on Schedule 1; that makes this situation suck a little more. But probably the alternative scenario is just the treatment remaining illegal forever.

[1] https://slatestarcodex.com/2014/06/15/fish-now-by-prescripti...

If I took shrooms, there is a nonzero chance I'd have a psychotic episode that could be fatal.

Can't say how many times I heard of anecdotal stories where a user just flipped personality out of the blue, it kinda steals away emotional resolution and wisdom from resolving issues if for example trauma is related to another person.

I didn't need mushrooms. I needed therapy, friends, a social life, a sex life, goals, something to look forward to in the real world.

All I found on mushrooms at the time were horrible existential loops that just made things more hopeless. I would read about people having these peak wonderful experiences or Mckenna alien experiences and just get more depressed that even the mushrooms didn't help me.

It is almost blasphemous in this space to say what actually ended up changing my life were SSRIs. A little prozac fixed something that was just chemically wrong in my head.

What seems obvious is there is enormous variability in people's brain chemistry so the tool to fix the problem has to be quite specific for the individual.

And N=1 but I can say without any doubt that LSD (and a pretty low dose at that, 50ug at once plus some microdosing) played an immense role at recovering from burnout. It was like night and day even after such a low dose that I _knew_ I recovered.

Those are amazing and powerful but also potentially dangerous substances and it’s a crime that we don’t allow everyone to get the benefits by, if not freely legalize it, at least adding those in the medical toolbox.

https://akjournals.com/view/journals/2054/7/S1/article-p22.x...

  > "Researchers have called attention to the ways that the hype promoting psychedelics as miracle cures 
  replicates preceding claims about the efficacy of SSRIs and other antidepressants in prior decades. 
  As the drug historian David Herzberg articulated in conversation with UC Berkeley's The Microdose:

    There’s been an enormous amount of money invested in psychedelics as people hope that they 
    can be the real Prozac in the same way that Prozac hoped it would be the real Valium and 
    Valium would be the real barbiturates, which would be the real morphine. 
    There’s a long history of hoping that maybe this time, it’s not so complicated; 
    maybe there is a simple switch to change people without having to change any [other] aspect of their [lives].

  While others have noted similarities between the earlier SSRI hype and the ongoing hype for psychedelic medications,
   the rhetoric of psychedelic hype is tinged with utopian and magico-religious aspirations that have no parallel 
   in the discourse surrounding SSRIs or other antidepressants. I argue that this utopian discourse provides insight 
   into the ways that global financial and tech elites are instrumentalizing psychedelics as one tool 
   in a broader world-building project that justifies increasing material inequality. 
   This elite project reveals how medicalized psychedelics can potentially undermine the very prosocial and 
   pro-environmental outcomes that the field's funders insist psychedelics will promote. 
   To understand the envisioned role of psychedelics within this elite project, this paper analyzes a different 
   parallel hype, revealing correspondences between the psychedelic industry hype and the concurrent 
   hype surrounding artificial intelligence (AI), including the Large Language Models (LLMs) that power ChatGPT. 
   The presence of these parallels is understandable when one considers their underlying affinities, 
   like two blooms from one plant: the same Silicon Valley and venture capital forces are investing 
   enormous amounts of capital to develop both as cultivars in their own image, 
   selecting for desired traits that further the existing socioeconomic order.

To be clear, this compound they're testing is also a Schedule 1 drug. COMP360 is their name for their psilocybin formulation. It's not a separate chemical, it is literally psilocybin.

Schedule 1 drugs can be used in clinical trials. Positive results in a clinical trial does not automatically remove the Schedule 1 designation. The medication is not approved yet and the clinical trial results are preliminary.

When suffering from depression lifestyle changes are HARD, especially when dealing with co-morbid mental or physical illness. Conversely a healthy adult of sound mind and body shouldn’t have too much problem deciding that exercise and going outside is beneficial, then just… doing it.