If you pull the data together it shows that the best way to get a response is to send a short message early in the morning (during his peek email hours): "the one time I reply to more email than I get is the 5am to 7am time frame."

Pretty good place to start if you want to get a response.

My original submission title was "Fred Wilson's Email Stats (and the secret to getting a response from him)". Looks like a Hacker News moderator edited my title, even though Fred talks about the secret to getting a response from him at the end of his post.