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Revanced is a mod for the official Android app, where NewPipe is an original app.

In practice this means that Revanced will be much more feature complete than NewPipe.

It also means revanced is legally dicey whereas newpipe is essentially a legal frontend/scraper of YouTube.

Revanced is only distributed as patches, probably to avoid being susceptible to the claims against the original Vanced.

Worth noting that ReVanced has a lot more patches than just YouTube.

Not that I care about it but I'm sure you are also violating some terms of service by using NewPipe

A trained monkey to operates the controls for me.

NewPipe has many features that the official app doesn’t, such as speeding up videos up to 5×.

Revanced supports up to 5x too.