Semaglutide improves knee osteoarthritis independant of weight loss

But it does make me wonder. If evolution was so concerned about blood sugar control it led to insulin release even before you ate (and that in evolutionary terms foods were very low in sugar and simple carbs). What must a doughnut do to our physiology?

[0] https://www.sciencedirect.com/science/article/abs/pii/002604...

A drug that influences a hormone causing effects on everything that hormone is involved in shouldn't be considered a wonder drug, it should be expected functionality.

It's only a wonder drug that does all these miraculous things if you think GLP-1 is only a weight management hormone. It's not, and you should expect effects anywhere it is involved in. A short list of tissues we know GLP-1 is involved in processes is:

- heart - tongue - adipose tissue - muscles - bones - kidneys - liver - lungs

Effects on these aren't miracles, they should be expected.

I am happy to hear you saw so many improvements, but it's because you had an issue with a hormone that is involved in a lot of things in the body. So it was going to express a lot of problems. It's not surprising that you see a lot of improvements when you begin to manage the underlying cause.

Only a magnesium drink ("Milk of Magnesia") or bisocodyl, neither of which are pleasant to take regularly as they result only in diarrhoea

It's hard to balance trying to let your body do its thing with less extreme method and resorting to the nuclear option. You also have to write off a day and not go anywhere after taking those

It's very much related to the drug and not just "ignoring" something

Vitamin C is a water soluble vitamin. It’s pretty damn hard to get Vitamin C toxicity from overconsumption. It’s not really something to worry about. This is true for all the water soluble vitamins.

This isn’t true for the fat soluble vitamins. Those are Vitamin A, Vitamin E, Vitamin K and Vitamin D.

You can overdose and get toxicity if you consume too much of these. For Vitamin D you can’t overdose from what your body generates from the skin but you can from the oral forms.

These are real, but they're also not permanent, and are why you start on a low dose to evaluate how your body reacts to the medication. My spouse is a long time GLP-1 user (coming up on four years now) and had mild (or more) bouts of several of these digestive related systems.

However, within six months these had greatly diminished. And by the one year mark, even at the highest dose, they were essentially gone and have remained a non-issue since.

You should certainly be mindful of side effects, and follow the recommended dosage scale up, which should be monitored by your doctor.

>I was on my thiccboi swag for the latter half of last year and am presently working it off by rebuilding my fitness base with kettlebells and cardio. I'd rather do this than GLP-1s not because I'm some sort of iron-willed badass so much as I'm simply distrustful of anything that messes with one's metabolism so severely. While these drugs are useful for the morbidly obese and diabetics I simply can't imagine how or why anybody would go on them for aesthetic or off-label purposes.

I do think folks with obesity fall into one of two camps (or somewhere on a spectrum between): those that are in that place because they don't put in any effort, eat whatever they want, don't workout, and so on.

And then there are folks like my spouse. They were able to lose weight in the past, but only through continued suffering. To be "just" overweight, they needed to be working out constantly and in a state of always feeling hungry. They never reached an equilibrium where it wasn't agony to maintain that weight, and after months/years would always rebound.

For them, a GLP-1 was the only thing that ever quieted the food noise. They workout constantly still and are in the best shape of their life. It wasn't entirely the GLP-1, but that gave them the tool to quiet the noise and get to a state where fitness could be fun/sustainable, and now they're killing it.

So, the TL;DR is that some people need this tool, and it's not necessarily an either/or. It can be one part in a series of positive changes that lead to better health and well-being.

That's not a judgment thing on my part - I've got a freezer full of Chinese peptides, among other things.

But the raw API on all of this stuff is coming from China in a way that is effectively unregulated and with no recourse if anything goes wrong. Underground Chinese labs get raided and shut down (usually because they're also involved in producing AAS or opioid precursors) often leaving millions of dollars in unfulfilled product. People get peptides with 0 active ingredient. People get peptides contaminated with disinfectant and have adverse reactions. People get mislabeled peptides. People get radically underdosed or overdoses peptides. And when a controversy hits, these labs close up shop one day and come back a week later under a new name. If you get a vial full of something truly harmful to you and you die, your loved ones have zero recourse.

Your local weed dealer has infinitely more accountability than these labs.

Testing isn't a panacea - people do endotoxin, heavy metal, HPLC, etc., but GCMS and similar basically never happens - and without knowing what the potential substances are the automatching to peaks even for GCMS is often inaccurate to the point of uselessness."Purity" reports on HPLC don't measure everything in the vial - just how pure the targeted peak is. It'll catch protein depredations, but it wouldn't tell you if there was a bunch of anthrax in the vial.

For me, the calculus still makes sense. I've got access to things that have worked incredibly well for me that are not yet available in the US, or in some cases, not likely to ever be. But the "gray" market is buying from overseas drug dealers that don't particularly give a fuck about you. They don't want to hurt you - you spend less money if they do - but they also aren't going out of their way to look after you. Most of them only started HPLC tests because the bodybuilding community demanded it, and these guys were selling AAS and HGH to them before they got into the GLP-1s, and then it became the standard.

These aren't parallel import goods getting sold in areas where they aren't supposed to or unauthorized retailers. These are drug dealers that get shut down by the Chinese government on a regular basis. Go look up QSC, SSA, SRY - and those are just some of the biggest names from the past year or so.

I think on retrospect deadlifts may have been my issue to, I did the deadlifts that day and later remember going to pickup something off the ground and getting the issue. Not sure if the deadlift was the cause, but I always thought my muscles were sore/tired and lax, thus when I went to lift the thing my lower back stability was compromised.

I'll try Romanian deadlifts and those other exercises, thanks for that suggestion.

I just don't like the stimulus to fatigue ratio for them and spend more time with cables, machines, and dumbbells than barbells these days.