I'm apart of the core team that delivers http://www.servicestack.net (A REST, RPC, SOAP + MQ Service framework) which we've been hosting for years on Linux, initially on CentOS and we're now on a Hetzner Ubuntu vServer which worked out to be 11x cheaper than a lower speced instance on Azure!:
https://speakerdeck.com/mythz/what-is-the-servicestack?slide...
We've gotten great up-time with Linux where our last server reached 480+ days up-time before we switched hosts: http://www.servicestack.net/mythz_blog/?p=838
There are other traditional Windows/.NET companies exploring deploying on Linux/Mono since it allows them to scale at $0 licensing cost, here's a post from 7digital showing how they deploy on Nginx/FastCgiMono using Capistrano: http://blogs.7digital.com/dev/2012/09/25/atomic-mono-deploym...
NancyFx (http://nancyfx.org) and SignalR (http://signalr.net) are other great .NET frameworks with Mono CI builds and first-class Linux Support.