There's 2 other performance things that you can do by controlling the runtime though - add special perf methods (which I did for draco decoding - there is currently one __mystralNativeDecodeDracoAsync API that is non standard), but the docs clearly lay out that you should feature gate it if you're going to use it so you don't break web builds: https://mystralengine.github.io/mystralnative/docs/api/nativ...
The other thing is more experimental - writing an AOT compiler for a subset of Typescript to convert it into C++ then just compile your code ("MystralScript") - this would be similar to Unity's C# AOT compiler and kinda be it's own separate project, but there is some prior work with porffor, AssemblyScript, and Static Hermes here, so it's not completely just a research project.