Politicizing this was one of the greatest electoral innovations of all time.
Somebody realized that calling people ignorant and telling them they had to do something pissed people off and lionized them. So they took the vaccine issue and made it political. They knew the "nerdy folks" would just continue pushing and prodding, and that would continue to rile up the other side's voters.
The "institutions" (which are easy to throw shade at) telling folks they had to comply or lose work - that's a cause to fight. There's much more energy in this than in opposing it, and opposition just inflames the other side even further.
Genius political move.
The correct response to a vaccine critic isn't to call them stupid or tell them they must get a vaccine or lose their job. The correct response is, "you do you, but the supply runs out next week".
Hank Green had a nice video essay about this (I'll try to find the link).
I grew up in the South. These are reasonable folks, and they can be reached, but it's being approached the wrong way. The current methodology is only making it worse.
This is like a viral "meme" that actually causes harm. And the more you try to get rid of it, the deeper it digs. You have to try a new approach. The current one -- and it feels so righteous to call them out -- does the exact opposite of what you want.