Blowing up something in the same orbit as the targets isn't an effective strategy. The explosion disperses the fragments into different orbits that intersect the original orbit only at one or two points. And even if some of those fragments find their targets, the collision velocity will be low (relatively slow).

It will be like getting hit with with shrapnels from a grenade. Depending on how they collide, the target may survive. If you think that grenade shrapnels are fast, you need to understand the 'hypervelocity impact' that happens when objects in different orbits collide, or when an interceptor hits a satellite. Hypervelocity impacts are impacts where the impactor moves faster than the speed of sound in the solid target. What that means in practice is that the debris/interceptor may have hit one end of the satellite and vaporized already, while the other end of the satellite doesn't yet feel the shock and vibration from that impact. That end doesn't yet know about the carnage that's about to hit it in a few milliseconds.