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CDPR is a Polish company though, so how is US law relevant?

DMCA is US law, that's how.

Hmm I'd say their takedown has no value then?

Unless they have a business presence in the US and sent it from there.

They have a business presence in the US, and sent it there.

The takedown is (also ? first and foremost ??)'against' Patreon, a USA company.

Because they invoked DMCA?