(Just to be clear, I'm not remotely an actual rocket scientist. I'm a transport planner / urban designer who specialises in Personal Rapid Transit systems, and starts companies on the side for fun; I've just spent an inordinate amount of time in pubs with fairly eminent rocket scientists, and have acquired an Opinion or two along the way. Plus, I need to keep one foot planted firmly in that world, so that once I've made my fortune elsewhere, I can move on to colonising the inner solar system without delay...).
Personally, I've always tended to be more of a VTVL guy, but anyone who can make wings work certainly has my support. In the case of of Reaction Engines / Skylon, I have to confess a bit of skepticism -- not from a technical point of view (the credentials and capabilities of the team are superb), but from a business-plan point of view. I've done various offhand models to get it to work, and the financing costs always kill it. It only works if you presuppose A.) an existing launch market of about 250-500 Skylon-class payloads per year, and B.) that SpaceX or Blue Origin haven't succeeded in lowering launch costs with their flyback boosters etc.
In contrast, SpaceX has a much more bootstrap-able evolutionary path, which allows them to largely avoid financing costs, and to theoretically get their customer prices closer to their marginal costs much more quickly. My feeling has always been that Reaction Engines ought to focus more on the possibilities for aviation, since it is a large enough market that it could absorb the R&D / finance costs much more easily. Once you're turning a profit in that market, then use it to bootstrap Skylon.
All IMHO, of course!