The Mona Lisa example actually supports both our positions in my opinion: someone can have a profound experience of it knowing nothing of Leonardo, while someone else has a different profound experience knowing his biography. Neither experience is 'false', they're just different modes of engagement with the same work. Personally, I have even experienced the inverse throughout my life.
Growing up not speaking English, and being flooded with American culture through radio, I was deeply moved by lots and lots of music made by foreigners that sounded like absolute gibberish to me. Later in life, after learning about the meaning of certain songs, I, unfortunately, lost some of my appreciation for it. Some may call that alienation, but to me it was a form of naivety of a child that enjoyed just sound in its pure form without it being tainted by any derived or supplied meaning from its creator that was attached to it through accompanied lyrics.