However, I feel that Lapham's is unique in that it picks a single topic for an issue, and then goes into great depth on that topic by interleaving primary sources and analysis.
Like the New Yorker and Vanity Fair, and unlike the Atlantic or the NYT Magazine, Harper's prefers on-the-ground reporting over covering "issues" or "trends". But the writing quality in Harper's tends to be much superior to that of both the New Yorker and Vanity Fair. Harper's best features are usually non-mainstream, and even intentionally bizarre stories.
A few years ago, Gawker had a great review of Harper's, called "Harper's Doesn't Want To Grow Up": http://gawker.com/5042234/harpers-doesnt-want-to-grow-up
To get a taste of Harper's, take a look at their regular science column, which I find hilarious. Here's the last one: http://harpers.org/archive/2012/10/0084112. I post it to HN every month but it never gets more than a few votes...
I can't imagine that in-depth scientific articles would garner much interest from hackers. You might be better off with technology-oriented pieces.