In many industrial applications, the concern is mostly control of the isolated side, like because that could physically destroy stuff. Exfiltration is a smaller or nonexistent concern, since you're already sending most data out deliberately.

So there's still an attack surface, but it's a lot smaller. Any side channel exploit would need to work (at least in some initial form) without changes to the software on the isolated side, since you otherwise can't bootstrap your way to installing it.

If I gave away a PC with perfect RF isolation and a rock solid supply chain it wouldn’t improve most user’s overall security because their operational security is so poor. There is no need for any organization to snoop your RF when you’re leaking everything they care about in your metadata.