He never said he doesn't advocate performance. He said performance should not be achieved by sacrificing abstractions.
>In addition, it sounds you mostly agree with regard to rewriting in C... use it as a last resort.
In CPython, not necessarily in Guido's advice, it's one of the first and most common things you hear about performance. "Just write parts of it in C".
If that was the advice of the early JVM guys ("just write parts of it in JNI"), we would never have gotten a fast JVM.