The least squares and pca minimize different loss functions. One is
sum of squares of vertical(y) distances, another is is sum of closest distances to the line. That introduces the differences.
OLS assumes that x is given, and the distance is entirely due to the variance in y, (so parallel to the y axis). It’s not the line that’s skewed, it’s the space.
And how I suppose. PCA is effectively moment matching, least squares is max likelihood. These correspond to the two ways of minimizing the Kullback Leibler divergence to or from a gaussian distribution.