If anything this is the challenge with PC as a platform being so varied, any random software/hardware/config variation could bring a whole load of quirks.

That probably includes anything that isn't a PC in a time-capsule from when the game originally released, so any OS/driver changes since then, and I don't think we've reached the point where we can emulate specific hardware models to plug into a VM. One of the reasons the geforce/radeon drivers (eg, the geforce "game ready" branding) are so big is that they carry a whole catalogue of quirk workarounds for when the game renderer is coded badly or to make it a better fit to hardware and lets them advertise +15% performance in a new version. Part of the work for wine/proton/dxvk is going to be replicating that instead of a blunt translation strictly to the standards.