Author here.

Thanks for the feedback everyone. I appreciate your posting it @woodenchair and @aurornis for pointing out the intent of the article.

The idea of the article is NOT to suggest you should shave 0.5ns off by choosing some dramatically different algorithm or that you really need to optimize the heck out of everything.

In fact, I think a lot of what the numbers show is that over thinking the optimizations often isn't worth it (e.g. caching len(coll) into a variable rather than calling it over and over is less useful that it might seem conceptually).

Just write clean Python code. So much of it is way faster than you might have thought.

My goal was only to create a reference to what various operations cost to have a mental model.