You'll always get something like this:
``` 00000000 : 00 01 02 03 04 05 06 07 00000008 : 08 09 0A 0B 0C 0D 0E 0F ```
On a big-endian machine, when you wrote 0x1234 to address 0x0000000 you got:
``` 00000000 : 12 34 02 03 04 05 06 07 00000008 : 08 09 0A 0B 0C 0D 0E 0F ```
On a little-endian machine you have to either do mental gymnastics to reorder the bytes, or set the item size to match your data item size.
``` 00000000 : 34 12 02 03 04 05 06 07 00000008 : 08 09 0A 0B 0C 0D 0E 0F ```
If we wrote the bytes with the LS byte on the right (just as we do for bits) then it wouldn't be an issue.
``` 00000000 : 07 06 05 04 03 02 12 34 00000008 : 0F 0E 0D 0C 0B 0A 09 08 ```