I love the conviction with which you say that.
So, there is no difference between compounds that we've evolved to consume over millions of years, and ones which were designed in the last 30 to be as addictive and as cheap to make as possible?
While I do not claim that there is evidence of difference (I cannot provide any), it is unfounded to claim that there is none, whether based on some (inherently) limited study of effects, or just based on lack of knowledge otherwise.
To be clear, I'm NOT talking about "Honest to god freshly squeezed tropicana juice", which is stretching the definition of what "squeezed orange juice" means (In case you are not aware - they boil it in vacuum, which gives it a much longer storage and shelf life, but kills taste and probably also any nutritional value; flavor is later added with a market-specific artificial "flavor kit" before packaging to consumers).
I'm talking about actually taking an orange, squeezing that, and drinking it. Which should be the only acceptable definition for "orange juice", I think.