When deployed on a popular server, one bit of "IP intelligence" this detector itself can gather is keep database of lowest-seen RTT per given source IP, maybe with some filtering - to cut out "faster-than-light" datapoints, gracefully update when actual network topology changes, etc.
That would establish a baseline, and from there, additional end-to-end RTT should become much more visible.
I imagine any big CDN implementing something like this could keep a database of all of this, combined with the old kind of IP intelligence and collecting not only RTT on other protocols like TLS, HTTP, IP (aka ping, and traceroutes too), TCP fingerprint, TLS fingerprint, HTTP fingerprint...
And with algorithms that combine and compare all these data points, I think very accurate models of the proxy could be made. And for things like credit card fraud this could be quite useful.