Bootstrapping a clean python env is the single biggest problem for people that are not daily coding in python.
That's half of the community in the python world.
When you write sqla that's not obvious, because you know a lot. But for the average user, uv was a savior.
I wrote a pretty long article on that here:
https://www.bitecode.dev/p/why-not-tell-people-to-simply-use
We also discuss it with brett cannon there:
https://www.bitecode.dev/p/brett-cannon-on-python-humans-and
But the most convincing argument is to teach python to kids, accountants, mathematicians, java coders and sysadmin.
After 20 years of doing that, I saw the same problems again and again.
And then uv arrived. And they disapeared for those people.