Nagle himself says (or said 10y ago) that the real culprit is delayed ACK: https://news.ycombinator.com/item?id=10608356

I’m no expert by any means, but this makes sense to me. Plus, I can’t come up with many modern workloads where delayed ACK would result in significant improvement. That said, I feel the same about Nagle’s algorithm - if most packets are big, it seems to me that both features solve problems that hardly exist anymore.

Wouldn't the modern http-dominated best practice be to turn both off?